An international team of scientists says they have identified a gene that appears to curb coffee consumption. People with a variation in the PDSS2 gene tend to drink fewer cups of coffee, according to the study (“Non-additive Genome-wide Association Scan Reveals a New Gene Associated with Habitual Coffee Consumption”), which is published in Scientific Reports.
Experts say the findings suggest that the gene reduces the ability of cells to break down caffeine, causing it to stay in the body longer. Thus, a person would not need to consume as much coffee to get the same caffeine hit, the team says. The findings add to previous studies that have identified genes linked to coffee habits and shed new light on the biological mechanisms of caffeine metabolism.
Researchers looked at genetic information from 370 people living in a small village in southern Italy and 843 people from six villages in northeastern Italy. Each of the study participants was asked to complete a survey that included a question about how many cups of coffee they drank each day.
The team found that people with the PDSS2 variation tended to consume fewer cups of coffee than people without the variation. The effect was equivalent to around one fewer cup of coffee per day on average. The investigators replicated the study in a group of 1731 people from The Netherlands. The result was similar, but the effect of the gene on the number of cups of coffee consumed was slightly lower. This could be because of the different styles of coffee that are consumed in the two countries, the researchers say. In Italy, people tend to drink smaller cups such as espresso whereas in The Netherlands the preference is toward larger cups that contain more caffeine overall.
The study was conducted at the Universities of Edinburgh and Trieste, the Burlo Garofolo Pediatric Institute in Italy, the Erasmus Medical Center, and PolyOmica, a data analysis company based in Groningen, The Netherlands.
Researchers from the Italian coffee company Illy also participated in the project, although the company did not offer financial support.
Nicola Pirastu, Ph.D., a Chancellor’s Fellow at the University of Edinburgh’s Usher Institute, noted that “The results of our study add to existing research suggesting that our drive to drink coffee may be embedded in our genes. We need to do larger studies to confirm the discovery and also to clarify the biological link between PDSS2 and coffee consumption.”