Collaborators will use the Biotage Initiator on more radionuclides and probes to create novel agents.

Biotage and McMaster University have agreed to extend their molecular imaging development agreement for another two years. The next research phase will expand microwave synthesis to a broader range of radionuclides and probes used in PET imaging and as therapeutic agents.

McMaster University researchers successfully completed the first year of the research agreement using the Biotage Initiator™ microwave synthesis system to prepare a range of carborane cage structures labeled with rhenium and technetium (Tc99c). They reported an 85% reduction in synthesis time and 26% gain in decay-corrected yield when compared to the traditional synthesis methods.

“The speed, purity and flexibility of this approach will drive the development of a new generation of novel molecular imaging agents,” according to John F. Valliant, Ph.D., associate professor of chemistry and medical physics and acting director of McMaster Institute of Applied Radiation Sciences.

As a result of its previous success, McMaster University has created the Biotage Molecular Imaging demonstration laboratory, which will offer other researchers the opportunity to see the technology working in a real radiochemistry environment and have first-hand experience with the tools that Biotage offers.

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