Anticancer Candidate Dampens Epigenetic Mechanism That Contributes to Lifelong Stress Susceptibility

The results of research by scientists at the Icahn School of Medicine at Mount Sinai suggest that an epigenetic modification that occurs in a major cell type in the brain’s reward circuitry controls how stress during early life increases susceptibility to additional stress in adulthood. Their studies, in mice, also showed that a clinical-stage small molecule anticancer candidate, pinometostat – which acts to inhibit the enzyme responsible for the observed modification – was able to reverse increased vulnerability to lifelong stress in animal models.