Age-Related Macular Degeneration Linked to Diet High in Refined, Processed, and Fried Foods

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Senior Male With Macular Degeneration
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Participants who ate a diet high in red and processed meat, fried food, refined grains, and high-fat dairy were three times more likely to develop an eye condition that damages the retina and affects a person’s central vision, according to the results of a study, “Diet patterns and the incidence of age-related macular degeneration in the Atherosclerosis Risk in Communities (ARIC) study,” from the University at Buffalo (UB) that appears in the British Journal of Ophthalmology.

The condition is called late-stage age-related macular degeneration (AMD), which is irreversible and affects a person’s central vision, taking away their ability to drive, among other common daily activities.

“Treatment for late, neovascular AMD is invasive and expensive, and there is no treatment for geographic atrophy, the other form of late AMD that also causes vision loss. It is in our best interest to catch this condition early and prevent development of late AMD,” said Shruti Dighe, who conducted the research as part of her master’s in epidemiology at UB’s School of Public Health and Health Professions.

And that’s why the finding that diet plays a role in AMD is so intriguing, added Dighe, who is now pursuing her PhD in cancer sciences at Roswell Park Comprehensive Cancer Center.

It turns out that a Western dietary pattern, one defined as high in consumption of red and processed meat, fried food, refined grains, and high-fat dairy, may be a risk factor for developing late AMD.

The authors studied the occurrence of early and late AMD over approximately 18 years of follow-up among participants of the Atherosclerosis Risk in Communities (ARIC) Study. Dighe and colleagues used data on 66 different foods that participants self-reported consuming between 1987 and 1995 and identified two diet patterns in this cohort: Western and what researchers commonly refer to as “prudent” (healthy) that best explained the greatest variation between diets.

“AMD is the leading cause of irreversible vision loss among the elderly. This study aimed to determine the association between dietary patterns and food groups (used to make them) with the 18-year incidence of AMD.

“ARIC participants who showed change in AMD lesions between retinal photographs taken at visit 3 and visit 5 were graded side by side to determine incident AMD (any=144; early=117; late=27). A 66-line item food frequency questionnaire, administered at visit 1 and visit 3, was used to identify 29 food groups. Principal component analysis was used to derive dietary patterns from average food group servings. Logistic regression was used to estimate ORs and 95% CIs for incident AMD (any, early, and late) by tertiles of dietary pattern scores, adjusted for age, race, education, total calories, and smoking status. P-trend was estimated using continuous scores.”

Western (unhealthy) and Prudent (healthy) dietary patterns were identified. No significant associations were observed between either dietary pattern and incident any or incident early AMD. However, a threefold higher incidence of late AMD was observed among participants with a Western pattern score above, as compared with below, the median (OR=3.44 (95% CI 1.33 to 8.87), p-trend=0.014).

“The risk of developing late AMD was decreased, but not statistically significant, among participants with a Prudent pattern score above, as compared with below, the median (OR=0.51 (95% CI 0.22 to 1.18), p-trend=0.054).

“Diet patterns were not significantly associated with incident any or incident early AMD. However, consumption of a Western pattern diet may be a risk factor for development of late AMD.”

“What we observed in this study was that people who had no AMD or early AMD at the start of our study and reported frequently consuming unhealthy foods were more likely to develop vison-threatening, late-stage disease approximately 18 years later,” said study senior author Amy Millen, PhD, associate professor and associate chair of epidemiology and environmental health at UB.

This U.S.-based study is one of the first examining diet patterns and development of AMD over time. The other studies were conducted in European cohorts.

Early AMD is asymptomatic, meaning that people often don’t know that they have it. To catch it, a physician would have to review a photo of the person’s retina, looking for pigmentary changes and development of drusen, or yellow deposits made up of lipids. With early AMD, there could be either atrophy or a buildup of new blood vessels in the part of the eye known as the macula.

“When people start developing these changes, they will begin to notice visual symptoms. Their vision will start diminishing,” Dighe said. “This is advanced or late-stage AMD.”

But not everyone who has early AMD progresses to the more debilitating late stage.

To date, most research has been conducted on specific nutrients, such as high-dose antioxidants, that seem to have a protective effect. But, Dighe explained, people consume a variety of foods and nutrients, not just one or two, and that’s why looking at diet patterns helps tell more of the story.

“Our work provides additional evidence that that diet matters,” Millen added. “From a public health standpoint, we can tell people that if you have early AMD, it is likely in your best interest to limit your intake of processed meat, fried food, refined grains, and high-fat dairy to preserve your vision over time.”

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