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February 15, 2012 (Vol. 32 , No. 4)

Protein A Media

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AbSolute® High Cap is a modified silica-based protein A media for capturing monoclonal and polyclonal antibodies from high-titer and large-volume fermentation feedstock. AbSolute High Cap offers high dynamic binding capacities (DBCs) and productivities at low and high velocities. DBCs (measured at 10% breakthrough) of 65, 55, 35, and 30 mg/mL at 250, 500, 1,000, and 1,500 cm/h, respectively, have been measured with human IgG. These performances are enabled by optimized particle size and uniform pore size distribution.

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