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The human brain has ~170 billion cells, with roughly 170 trillion synaptic connections, organized into distinct regions, structures, and cortical layers. This complex intersection between cellular connectivity and neuroanatomy has made it challenging to untangle discrete functions in health and disease. Spatial profiling at the single cell level makes it possible to move beyond deductive science and delve into the gene expression changes occurring in tissue micro environments during disease development and therapeutic response more directly.  

In this GEN webinar, our distinguished speaker Dr. Simon Gregory will demonstrate how 10x Genomics’ Xenium Mouse Brain Gene Expression Panel and a Custom Add-on Panel can be used to characterize therapeutic response in brain cancer and white matter injury repair. He will demonstrate the use of single cell spatial imaging with these panels to examine pathological processes associated with the development of diffuse midline glioma, and tumor response to a novel therapeutic intervention. He will also share results assessing the impact of a new oxysterol therapy on an intestinal perforation model of cerebral palsy. 

A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelist.

Simon Gregory
Simon Gregory, PhD
Prof. and Program Director, Dept. of Neurosurgery
Vice Chair of Research, Department of Neurology
Director of the Molecular Genomics Core, Duke Molecular Physiology Institute
Duke University School of Medicine