Advances in Cell and Gene Therapy: Characterizing Large Viral Vectors Using Macro Mass Photometry

Accurate characterization of large viral vectors is a critical step in developing viral vector-based gene therapies and vaccines for use in cancer immunotherapies, genetic disorders, infectious diseases, and more. This process is indispensable for ensuring the safety, stability, and efficacy of biopharmaceutical products. However, characterization methods are often time-consuming, requiring multiple orthogonal techniques.

In this GEN webinar, Dr. Laura Pala will discuss how macro mass photometry enables fast, qualitative analysis of adenovirus and lentivirus samples for cell and gene therapies. She will introduce Karitro^MP, a novel analytical instrument that uses macro mass photometry to characterize large viral vectors in research and development environments. During the webinar, she will share case studies and benchmarking data using adenovirus and lentivirus samples. The key learning objectives are:

• The advantages of using the Karitro^MP to characterize viral vectors at a single-particle level, based on contrast (proxy for mass) and particle size.
• How the Karitro^MP can identify empty or fragmented capsids in adenovirus preparations and assess the purity and quality of viral vectors.
• How macro mass photometry can be used to compare different production and purification methods and assess variations between batches.
• How to integrate the Karitro^MP throughout the cell and gene therapy development process.

A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelist.