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Understanding how cells organize the array of components within their membranous confines can not only provide insight into essential homeostatic functions it can also shed light on disorganized regions within the cell that may be an underlying cause of disease. The mechanistic feat cells perform to orderly arrange their contents and package vast amounts of material into such small boundaries is nothing short of remarkable. For instance, human DNA is two meters in length and must be packaged into the small space of a cell’s nucleus. Thankfully, new technologies, such as super-resolution microscopy, are helping to reveal how the genome is folded and packaged inside intact nuclei—providing investigators an immense assortment of novel research opportunities.

In this GEN webinar, our distinguished speaker, Dr. Melike Lakadamyali, will present her work on using super-resolution microscopy to visualize and quantify chromatin nanostructure in single cells. Moreover, we will hear how the chromatin nanostructure can be remodeled via chemo-mechanical cues and how degenerative chemo-mechanical cues during disease, like in tendinosis, can lead to altered chromatin nanostructure, potentially impacting cell phenotype.

A live Q&A session followed the presentations, offering you a chance to pose questions to our expert panelists.


Webinar produced with support from:

Melike Lakadamyali, PhD
Melike Lakadamyali, PhD
Associate Professor
University of Pennsylvania