Anjali A. Sarkar, PhD

Anjali A. Sarkar, PhD wrote a new post, Hair Regeneration Requires Regulatory T Cells Signal Skin Stem Cells 4 days, 14 hours ago

Alopecia is an autoimmune disorder where immune cells attack and destroy hair follicles, causing hair loss. Uncovering a molecular target of a common treatment for alopecia in a new study, scientists at the Salk […]

Anjali A. Sarkar, PhD wrote a new post, Memory Loss in Alzheimer’s Disease Pivots on Urea Metabolism 5 days, 13 hours ago

Targeted inhibition of an enzyme linked to the urea cycle called ornithine decarboxylase 1 (ODC1) in star-shaped cells in the brain called astrocytes, could prove beneficial in restoring memory functions in […]

Anjali A. Sarkar, PhD wrote a new post, Recoding the Genetic Code to Integrate Selenocysteine 6 days, 13 hours ago

The essential balance of redox reactions, protein synthesis and folding, protection of cell membranes, and integrity of genomic DNA depends on a handful of proteins called selenoproteins that include the trace […]

Anjali A. Sarkar, PhD wrote a new post, All-in-One AAV Delivery Realized by a Compact Base Editor 1 week, 3 days ago

A study published last week presents a compact base editor that enables efficient in vivo delivery using a single adeno-associated virus (AAV) vector. The innovation, once approved in clinical trials, could lower […]

Anjali A. Sarkar, PhD wrote a new post, Proteome Diversity at Centrosomes Uncovers Neurodevelopmental Disease Mechanisms 1 week, 4 days ago

When cells extend, move, or divide, a tiny organelle called the centrosome provides a cytoskeletal anchor and regulatory hub. It was long held that centrosomes are similar in composition across cells. But a […]

Anjali A. Sarkar, PhD wrote a new post, Aging Peptidoglycans Control Outer Membranes in Bacteria 1 week, 5 days ago

In the past few decades, many Gram-negative bacteria have acquired multi-drug resistance, compounding the global threat to public health. Many pathogenic bacteria, including those that cause dysentery, pneumonia, […]

Anjali A. Sarkar, PhD wrote a new post, Addiction Maps to Common Neural Network in Humans 1 week, 6 days ago

Local damage such as stroke lesions in the brain can lead to spontaneous remission from addiction, where patients can easily quit their addictions immediately following injury, with no cravings or relapses.

An […]

Anjali A. Sarkar, PhD wrote a new post, Longevity Lessons from Lysosomes 2 weeks, 3 days ago

Long recognized as the cell’s recycling depot, a new study has found lysosomes act as signaling hubs that coordinate metabolism and longevity by communicating signals across tissues.

According to a 2019 U […]

Anjali A. Sarkar, PhD wrote a new post, Physical Performance Boosted by Ion Channel Gene Variant in Mice 2 weeks, 4 days ago

Tendons are stretchy bands of connective tissue that connect muscles to bones. A new study shows, a variant of a gene that encodes an ion channel in tendons that is sensitive to mechanical pressure, can make mice […]

Anjali A. Sarkar, PhD wrote a new post, Alzheimer’s Pathology Could Benefit from Activating Microglial Targets of Rapamycin 2 weeks, 5 days ago

Serendipitously discovered as an antifungal agent from soil samples, rapamycin is used as an immunosuppressant in patients with transplantation, cancer, and neurological disorders, and is believed to reduce […]

Anjali A. Sarkar, PhD wrote a new post, How SARS-CoV-2 Selection Increases with Convergent Evolution 2 weeks, 6 days ago

Despite the speedy development of effective vaccines, therapeutic antibodies, and antivirals, the emergence of viral variants continues to prolong the COVID-19 pandemic.

A new study featured in the journal […]

Anjali A. Sarkar, PhD wrote a new post, Diabetes Drug May Also Reduce Risk of Alzheimer’s Disease 3 weeks, 3 days ago

In a recent study, scientists at the Karolinska Institute in Stockholm, Sweden, and the National Institute of Aging, investigate the association between the risk for Alzheimer’s disease (AD) and genetic v […]

Anjali A. Sarkar, PhD wrote a new post, Breast, Brain, Pancreatic and Ovarian Cancers Can Be Tackled by Triggering ER Stress 3 weeks, 4 days ago

A meshwork of membranous tunnels studded with protein and lipid manufacturing units crisscross the cytoplasm of all nucleated cells. In a range of cancers, including pancreatic, glioblastoma and ovarian cancers, […]

Anjali A. Sarkar, PhD wrote a new post, Age Interacts with Mutations, Clonal Growth and Cancers of Blood Cells 3 weeks, 5 days ago

With time, genes in all cells of the body incorporate mutations. When blood cells pick up specific “driver” mutations, they divide and multiply faster than their peers, to form populations with identical mut […]

Anjali A. Sarkar, PhD wrote a new post, Drug Resistant Tuberculosis Could be Treated with Derivative of Tropical Plant 3 weeks, 6 days ago

A new preclinical study conducted on rat models and published on May 31, 2022, reports the discovery of a new class of drugs that could prove effective in treating patients infected with drug-resistant strains of […]

Anjali A. Sarkar, PhD wrote a new post, Autism Affects Visual System Development in Pre-Symptomatic Infants 1 month ago

A new study published reports that social deficits in children diagnosed with autism spectrum disorder (ASD) correlate with early structural and connectivity traits particularly in the visual circuitry of the […]

Anjali A. Sarkar, PhD wrote a new post, Z-DNA Triggering Drug Kills Immunotherapy Resistant Melanoma by Mimicking Flu 1 month ago

In a new study, scientists have identified a small molecule candidate drug that triggers the formation of left-handed Z-DNA in cells that in turn activates a highly immunogenic programmed pathway of inflammatory […]

Anjali A. Sarkar, PhD wrote a new post, Fetal Master Clock Genes Dance to Mother’s Beat 1 month ago

A new study uses time-resolved transcriptomic and proteomic data from fetal cells of the suprachiasmatic nucleus (SCN)—the master circadian clock in the hypothalamus of the brain—in rat models, to discover wid […]

Anjali A. Sarkar, PhD wrote a new post, Shape Shifting Immune Receptors Protect Plants from Microbes 1 month, 1 week ago

A recent study reported the discovery of a new mechanism that enables plants to fight against microbial infections.

Earlier studies have shown that breaking down NAD+ (nicotinamide adenine dinucleotide), a […]

Anjali A. Sarkar, PhD wrote a new post, New DNA Repair Mechanism Holds Promise for Precision Cancer Therapies 1 month, 1 week ago

Scientists at the University of Birmingham and the Francis Crick Institute have discovered a new way in which cancer cells repair double-stranded breaks in DNA.

The findings were published in a paper […]