GEN Magazine

May 2021 Vol. 41 No. 5

Feature Articles

Columns

Coronavirus COVID-19

New COVID-19 Vaccines May Reach Out to T Cells, Not Just B Cells

“Red flags” that prompt T cells to attack host cells infected by SARS-CoV-2 infection have been identified in studies with human cells. These red flags, which correspond to previously uncharacterized peptides derived from the internal proteins making up the SARS-CoV-2 virus, could enable a more precise selection of peptides for COVID-19 immune monitoring and vaccine development.
alzhimer's disease

Immunomodulatory Treatment Halts Alzheimer’s Disease Progression, Improves Cognition in Primates

Studies in aging squirrel monkeys showed how a form of immunomodulatory therapy can stimulate activity of immune defense cells and reduce levels of amyloid beta plaques and tau tangles that are linked with the pathology of Alzheimer’s disease. The research found that animals treated using CpG oligodeoxynucleotides had up to 59% fewer plaque deposits in their brains, and also lower levels of toxic tau, without excessive or sustained inflammation.

Mouse Model Reveals How the Pituitary Gland Ages

In a mouse-model study, researchers at KU Leuven have discovered that the pituitary gland in mice ages as the result of an age-related form of chronic inflammation. Their findings suggest the potential to one day slow down this process or help repair it.

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Coronavirus COVID-19

New COVID-19 Vaccines May Reach Out to T Cells, Not Just B Cells

“Red flags” that prompt T cells to attack host cells infected by SARS-CoV-2 infection have been identified in studies with human cells. These red flags, which correspond to previously uncharacterized peptides derived from the internal proteins making up the SARS-CoV-2 virus, could enable a more precise selection of peptides for COVID-19 immune monitoring and vaccine development.
alzhimer's disease

Immunomodulatory Treatment Halts Alzheimer’s Disease Progression, Improves Cognition in Primates

Studies in aging squirrel monkeys showed how a form of immunomodulatory therapy can stimulate activity of immune defense cells and reduce levels of amyloid beta plaques and tau tangles that are linked with the pathology of Alzheimer’s disease. The research found that animals treated using CpG oligodeoxynucleotides had up to 59% fewer plaque deposits in their brains, and also lower levels of toxic tau, without excessive or sustained inflammation.

Mouse Model Reveals How the Pituitary Gland Ages

In a mouse-model study, researchers at KU Leuven have discovered that the pituitary gland in mice ages as the result of an age-related form of chronic inflammation. Their findings suggest the potential to one day slow down this process or help repair it.

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