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February 21, 2014

Single-Cell Analysis Answers Multiple Questions

This broad research space has been garnering significant attention.

Single-Cell Analysis Answers Multiple Questions

The SCA space is composed of technologies on the “front end” for capturing the relevant cellular [sub]-populations and technologies on the “back end” for interrogating the captured cellular [sub]-populations. [© Chrisharvey | Dreamstime.com]

  • The focus of this GEN BioMarket Trends report is the expanding field of single-cell analysis (SCA), which is a broad and amorphous space. Highlights of the report:

    • Biological heterogeneity between cells is now becoming recognized as a key contributor to disease as is believed to be the case in cells derived from primary tumors that may possess alterations enabling them to see distant metastases.
    • In order therefore to understand and treat disease at the fundamental level, cell-cell differences within a population must be analyzed and appreciated—this opens up the realm of SCA, which is gathering significant attention.
    • In this report we provide an update on CTCs as a special case of SCA wherein some clinical utility of CTC measurements has been demonstrated.
    • Much work remains, however, in the realm of single-cell sequencing and single-cell genomics, and the industry is just beginning to recognize the importance of SCA.

    More reports will follow over the coming months analyzing different facets of the SCA marketplace.

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