In the biosciences, some advances can’t help but catch our eyes—and our imaginations. Take the emergence of super-resolution microscopy technology, the subject of this month’s cover story. Because the new technology allows us to pinpoint and track individual molecules in living cells, it amazes us almost as much as the earliest microscopes must have amazed van Leeuwenhoek once he used them to glimpse unsuspected “animalcules.” But let’s remember that the excitement of seeing new worlds isn’t limited to microscopists, or everyday scientists who now have access to user-friendly super-resolution platforms. As this issue of GEN demonstrates, new worlds are being revealed by other technologies. For example, organoid models, AI platforms, and epigenetic technologies are delivering drug development insights, and platform processes are showing how to streamline the manufacture of AAV gene therapies. Finally, as this month’s A-List details, NGS companies are introducing tools to widen genomics (and multiomics) explorations.