GEN Magazine

Volume 43, Issue No. 02, February 2023

GEN February 2023 cover

Structure-function relationships are central to much of GEN’s coverage. So, it should come as no surprise that this month, GEN is making a point of marking the 70th anniversary of the discovery of DNA’s structure. After all, the DNA double helix may be the best example we have of how structure-function relationships can work. As the discoverers of DNA’s structure stated, “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” To take inspiration from this kind of thinking, join GEN in commemorating the double helix’s discovery. Also, take the opportunity to appreciate the varied structure-function relationships embedded in this, the February issue. They are to be found, for example, in AI-driven protein engineering, the design of therapeutics and vaccines, and the development of molecular diagnostics.

Browse the print magazine as a flipbook

Browse the print magazine supplement as a flipbook

Website Content from This Issue

Spatial Biology Current State of the Art and What’s Coming Next

GEN Interview with Joseph M. Beechem, PhD, Chief Scientific Officer of NanoString Technologies

Joseph M. Beechem

Choosing the Right Spatial Technology

SMI Raw Data

Spatial and NGS Dominate Proceedings at AGBT 2022

CosMx SMI image

Spatial Technology Offers Spectacular Insights

A CosMx SMI image

Spatial CRISPR Genomics of Tumor Microenvironments

Spatial mapping of Pro-Code/CRISPR lung tumor lesions.

Reflections on the Double Helix’s Platinum Anniversary

ames Watson and Francis Crick

AI and Computational Design Advance Protein Engineering

Evozyne’s office in Chicago, IL

In Pursuit of Rare, Subtle, and Fleeting Post-Translational Modifications

Woman Checking label in lab

Managing Risk in Aseptic Processing Environments

Glass bottles in production in the tray of an automatic liquid dispenser, a line for filling medicines against bacteria and viruses, antibiotics and vaccines

Tripledemic Rouses Vaccine Developers and Variant Trackers

Clear Labs male worker

The Many Facets of Flow Cytometry

Nanovial illustration

Molecular Diagnostics Adapts to Evolving Diseases

Qiagen symphony

Enabling the Synthetic Biology Revolution


Making Medicines Based on Transplanting Differentiated Cells

Oligodendrocyte Progenitor Cells

Fueling Growth through Partnership in Greater Philadelphia

Chemists work on project in lab

Novel Discoveries in Spatial Biology with the Highest Image Quality

IHC and MIBI images

Advancing Plasmid DNA Manufacturing


Calculator #

Neurosurgical Atlas

Cell Culture—Learn, Experiment, and Calculate

Accelerating the Development of Sustainable Textile Dyes


Cost-Effective Products for Extracellular Vesicle Isolation

AMSBIO_extracellular vesicles

Lysis and Hypotonic Sonication Buffers for ChIP Assays


High Throughput Cell Density and Cell Viability Analysis


Nucleotide Novellas: Tessera Therapeutics Writes Genetic Medicines to Cure Diseases

reverse transcription