Structure-function relationships are central to much of GEN’s coverage. So, it should come as no surprise that this month, GEN is making a point of marking the 70th anniversary of the discovery of DNA’s structure. After all, the DNA double helix may be the best example we have of how structure-function relationships can work. As the discoverers of DNA’s structure stated, “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” To take inspiration from this kind of thinking, join GEN in commemorating the double helix’s discovery. Also, take the opportunity to appreciate the varied structure-function relationships embedded in this, the February issue. They are to be found, for example, in AI-driven protein engineering, the design of therapeutics and vaccines, and the development of molecular diagnostics.