GEN Magazine

Volume 43, Issue No. 07, July 2023

July 2023 cover

We’ve all heard the phrase “two-dimensional performance.” Usually, it’s a complaint about an actor being unnatural or unconvincing. But the phrase can also apply to cell culture. If it is in two dimensions, cell culture can lack physiological nuance, leaving questions about disease mechanisms and therapeutic responses unanswered. To arrange for subtler, richer performances, consider running cell culture auditions that include organoids and organ-on-a-chip systems. As the July issue of GEN shows, these 3D cell culture systems promise to become bankable stars in drug development.

The July issue also describes the growing popularity of ensemble casts. These are found in single-cell analyses, which are capturing the behaviors of individual cells more effectively though the application of machine learning and other computational technologies. Finally, the July issue is also full of ideas to improve casting calls for CAR-T, synthetic DNA, CRISPR screening, and viral surveillance technologies.

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Website Content from This Issue

Eliminating Blind Spots in Pandemic Preparedness

Influenza viruses

3D Cell Culture In Vitro Modeling Explores New Depths

Normal Cystic Colon Organoids

When Long Synthetic DNA Is Needed in Short Order

DNA sequencing blueprint RNA sequencing DNA computational models

Diverse Approaches, Common Goals Evident at Single-Cell/AI Symposium

Molecular universe, abstract scientific background

Solid Strategies for CAR T-Cell Immunotherapies

Atara Biotherapeutics employee in lab

CRISPR Screens Should Be Exhaustive, Not Exhausting

CRISPR-Cas9 proteins recognize and cut foreign pathogenic DNA

New Spinoff Means to “Rev Up” Omics

Revvity rang the opening bell at the NYSE

Where Has All the Talent Gone?

scientists in lab

OER Commons


AI Drug development


abm Learning Resources

Accelerating Tomorrow’s Vaccines with Ready-to-Use mRNA

Vernal lab

Paving the Way in Spatial Genomics

Vizgen sponsored content MERFISH data image

How to Choose Your 3D Assay with Confidence

InSphero sponsored content hero image

Case Study: Genetic Engineering of Adoptive Cell Therapies

Single-Cell Whole Genome Sequencing Is Needed to Assess the Safety of Genome Editing Therapies

BioSkryb Data Flowers illustration

Molecular Pixelation Kit for 3D Spatial Analysis of Cell Surface Proteins

Microbioreactor Light Array Module

Single-Cell Pooled CRISPR Screens

Mass Spectrometer for Biological Discovery

Higher Throughput, More Flexible Single-Cell Multiomics Analysis

Molecular universe, abstract scientific background

Microsoft Azure

Microsoft azure

Pipette Tips

Pipette tips thermo

Novartis to Buy Chinook for Up to $3.5B, Expanding Kidney Disease Pipeline

deSouza Resigns as Illumina CEO, as Fallout Continues from Icahn Challenge

ChatGPT-Like Model “Speaks Protein” to Speed Drug Discovery

Abstract glowing virtual neural network. Futuristic coding or Artificial Intelligence concept

Could Octopuses Arm the Field of Therapeutic RNA Editing?

Single Cell Sequencing and the AVITI™ System: A Perfect Pairing

Abstract colorful defocused cells. Abstract microscopic forms on a dark background

Live from Los Angeles, ASGCT Goes Prime Time

ASGCT 2023 Venue

ASGCT News: Nobel Laureate Jennifer Doudna Opens Presidential Symposium

Jennifer Doudna

ASGCT News: David Liu Hails Rapid Progress in Precision Genome Editing

David Liu speaks at ASGCT 2023