GEN Magazine

Volume 43, Issue No. 04, April 2023

April 2023 GEN Cover

Cancer is a slippery foe on multiple levels. So, anticancer efforts should proceed on multiple levels, too. For example, cancer finds refuge in the immunosuppressive tumor microenvironment (TME). Here, anticancer efforts include the development of therapeutics to improve checkpoint inhibition, assist immune infiltration, and block Treg recruitment. But what about cancer targets that are slippery because they present smooth surfaces—such as active sites with broad, shallow pockets? Here, too, there are emerging options. For example, “undruggable” cancer-associated proteins may be consigned to the proteosome—the cell’s garbage disposal unit—by targeted protein degraders. To learn how cancer is being attacked at multiple levels—by making the TME less hospitable, and by hitting a wider range of molecular targets—read the April issue of GEN. Other topics of interest in the April issue include CRISPR crop development, computational approaches to drug design, and biomimetic technology.

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Website Content from This Issue

Targeted Protein Degradation: A Promising Option for Cancer Drug Developers

Proteasome collaborate with ubiquitin to degrade proteins

Weaker Tumor Microenvironments, Stronger Immunotherapies


Regenerative Medicine Companies Explore Diverse Approaches


Computational Tools Take Advantage of the Data Deluge

conformational free energy landscape

Virtual Drug Design Promises Real Benefits

Molecular Forecaster

Biomimetic Technology: A Natural in Therapeutics Design

Peptide Backbone

CRISPR Crop Development Is Anything but Garden Variety

Timothy Kelliher, PhD, researcher at at Syngenta Seeds inspecting crop

Raise the Analytical Bar When Turning Oligos into Therapeutics

The Next Generation of Drugs Will Be Enhanced by Machine Learning

Protein Knockdowns May Obviate Genetic Knockouts

Amphista Therapeutics degraders

High-Plex Spatial Signatures Can Predict Responses to Immunotherapies

mitre phenoptics spatial proximity analysis

Precision Proteomics: A Change in Perspective

Alamar sponsored content

Revealing the Tumor Microenvironment’s Vulnerabilities


How Spatial Biology Can Enhance Understanding of TCR Diversity

T-cell receptors (dark blue), CD4 molecules (light blue), glycolipids (orange). The T-cell receptor activates the immune response to antigens in T-lymphocytes

Staining Automation at Every Bench for Better and more Reproducible Tissue Imaging

Complete Anatomy ’23




Zeiss Computed Tomography




Dyes to Enhance 
Multiplex Flow Cytometry

Automated AAV Capsid Analysis

Automated Liquid Handler

Cell Imaging for Laboratory Automation

World’s Longest Oligo Produced Using de novo Synthesis


Telomeres Encode Disease-Relevant Proteins

illustration of telomeres