GEN Magazine

Volume 42, Issue No. 03, March 2022

The metaverse has arrived—not the virtualized society imagined by techno-utopians, but the teeming, interacting community of microorganisms and their hosts. Actually, the latter metaverse—let’s call it the living metaverse—has been here all along. What’s new is our ability to plumb its depths, identify its components, and work out its dynamics. As this issue of GEN emphasizes, the living metaverse is most evident through metagenomics, the study of all the genomes that are to be found in mixed communities of organisms. And what can metagenomics do? It can improve diagnostics and infectious disease surveillance. Such are the benefits of seeing deeply and comprehensively. Seeing this way is possible in other disciplines, notably cancer genomics. Two articles in this issue of GEN describe how cancer genomics is advancing the discovery of pathogenic variants, the screening and stratification of patients, and the development of new drugs. Finally, the current issue highlights other areas in which fine detail and rich context matter. These areas include the development of CRISPR-based treatments, and the maintenance of cardiovascular health.

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Website Content from This Issue

Infectious Disease Experts Proclaim “Many Voices, One Health”

Human Corona Virus

Next-Generation Sequencing Boosts Clinical Metagenomics

COVID-19 coronavirus cells, DNA cell structure

Cancer Genomics: From Tiny Samples to Big Findings

Thermo Fisher Scientific’s Ion Torrent Genexus System and Oncomine Solution

Cancer Genomics: Streamlined Workflows for Reading and Writing DNA

Cancer cells on dna stand background

CRISPR Partnerships Seek Win-Win Situations

Man pushing a shopping cart with genetically modified food. Genetic engineering

Metagenomic Sequencing Moves to the Clinic

Three sheep

Opening New Lines of Attack against Cardiovascular Disease

Heart muscle structure

Precision Control of Culture Conditions for Induced Pluripotent Stem Cells

Embryonic stem cells

Serum-Free Media—Optimizing CAR T-Cell Therapy Production

CAR T cell immunotherapy, illustration

One-Step ADC Linker Approach Bypasses Antibody Engineering

Finding the Right Partner for Product R&D and Manufacturing

Samsung lab, pipetting

FISHing for Patterns in the Brain

Pattern in Brain

Image-Based High-Content Screening and Predictive Cell-Based Assays for Drug Discovery and Development

Geometric Background

Demystifying Autoimmune Diseases Using Patient-Centered Health Intelligence


Ultra-Fast Methods Yield COVID-19 Antibodies That Effectively Protect Immunocompromised

Virus or bacteria cells

Anti-Pertuzumab Antibodies

Flexible Format 
Light Scattering System

Low Dead Volume 
Reservoir Trays


NCATS OpenData COVID-19 Portal

Thermo Fisher Learning Centers

Gene Expression and Analysis Resource (gEAR)

Capsule Delivery Brings RNA Vaccine Pill One Step Closer

Magnesium Enables Immune Cells to Tackle Infections and Cancer

T lymphocytes and cancer cell