GEN Magazine

Volume 41, Issue No. 09, September 2021

Bioscience is a vast puzzle, which sounds like fun—until you remember that puzzles can be frustrating, especially if they’re missing crucial pieces. Fortunately, as this issue of GEN indicates, some of bioscience’s missing pieces are falling into place. Piece one: The tissue-level patterns formed by cells with disparate gene expression profiles. (These patterns, which influence health, are emerging because single-cell technology is being combined with spatial transcriptomics.) Piece two: A smooth Design-Build-Test-Learn (DBTL) cycle in synthetic biology. (DBTL still isn’t turning as freely as it might, but with new DNA-writing technology, more RPMs are expected.) Piece three: CAR T cells that could help more than a minority of cancer patients. (Such cells may be built if allogeneic approaches are used, or if genetic engineering is used to install ancillary immune signals.) So, if you want to solve bioscience puzzles—including those related to outsourcing and bringing NGS to bear in biomanufacturing—read our September issue.

Browse the print magazine as a flipbook

Browse the print magazine supplement as a flipbook

Website Content from This Issue

Enhancing Drug Development with Human Liver Spheroids

Spatial Transcriptomics Puts More Biology on the Map

spatial biology

CRISPR: New Techniques and Complex Models

blood smears from a humanized mouse model

CRISPR-Based Therapeutics Blaze an In Vivo Path to the Clinic

The Point of Base Editors: Correcting Point Mutations

Synthetic Biology Engineers the Next Genomic Revolution

high-throughput silicon platform

CAR T Cells: Off the Shelf and On the Mark

Chimeric antigen receptor (CAR) T cells

CROs: Yesterday, Today, and Tomorrow

Going Global in Bigger Ways

BioAgilytix lab

Next-Generation Sequencing Drives Progress in Biopharma

Researcher at Thermo Fisher Scientific’s campus in Carlsbad, CA

CRISPR Applications in Medicine Depend on Minimizing Off-Target Editing

Clearing the Way for a Synthetic Biology Tipping Point

DNA Script lab

Synthetic DNA in Drug Discovery and Development

DNA Molecule Structure

CRISPR-Cas9 Technology Cuts Clutter from Sequencing Libraries

Jumpcode Genomics lab

Single-Cell Biology across Tissues

Rebus Esper

Bringing Spatial Biology to the Clinic

mitre phenoptics spatial proximity analysis

Streamlining Small Molecule Discovery With Torx™

Spatial Phenotyping Adds a New Dimension to Discovery Biology

voronoi diagrams

New DECODR Software Breaks Through Limits on CRISPR Data Analysis

DNA binding process, illustration

Getting Hooked on MERFISH: A Core Lab’s Journey into Spatial Genomics

Colon Cancer

Industrializing CRISPR

A Bioprocess Success Story: Securecell Introducing IntegraOne

Securecell’s founder and CEO, Carlo Andretta

Single-Cell Proteomics Predicts Progression-Free Survival in Melanoma Study


Accelerating the Clinical Success of Gene Therapies through Viral Vector Engineering

mRNA Capping Technology

Unlocking Photochemistry in Flow

UV Measurement under Harsh Conditions

Automatic Sprayer

The Blue Brain Project Portal


American Philosophical Society Digital Library

The Online Macromolecular Museum