Chromatrap® buffer reagents have been formulated to act rapidly, gently, and efficiently, ensuring reproducible results with high chromatin yields from various sample types. With chromatin being at the heart of Chromatin Immunoprecipitation (ChIP), the extraction and purification of this condensed DNA is a vital starting point for epigenetics research. Chromatrap Hypotonic Buffer has been widely proven to provide effective disruption of cell membranes through swelling of the cells. Chromatrap Lysis Buffers are formulated to ensure the nuclear membrane is disrupted, releasing a high yield of nuclear material for your research. The Chromatrap Lysis buffer for enzymatic shearing provides users with a complete lysis buffer for the disruption of nuclear cell membranes containing a milder detergent than that required for mechanical fragmentation. Additionally, the Chromatrap Lysis buffer for sonication is formulated to ensure effective nuclear lysis and mechanical shearing for a range of different species of organism and is ideal for difficult to lyse cell types and tissues.