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June 1, Vol. 28, No. 11

  • Feature Articles

    • Ion Channels Play Key Role in R&D
    • David Daniels, Ph.D.
    • Maintenance of cardiac rhythm and pain sensation require the flow of ions across the membranes of all cells Ion channels, which facilitate this movement, are protein assemblies that penetrate the membrane and catalyze passage of specific ions such as sodium ... more »
    • PAT Initiative Helps Move HPLC Forward
    • Angelo DePalma
    • High-performance liquid chromatography (HPLC) has provided analytical support for biopharmaceutical research, development, and manufacturing for as long as biotech has existed Only recently, though, have HPLC, its methods and associated instrumentation achieved the speed, reliability, and robustness sufficient to analyze ... more »
    • Superbugs vs. Superdrugs: Race Goes On
    • Sue Pearson
    • At the recent “Superbugs and Superdrugs” conference in London, Nora Kaarela, CEO of Ipsat Therapies (wwwipsat-thercom), commented, “Hospital-acquired bacterial infections are a leading cause of death in the US, and it costs between $16,000 and $100,000 per patient to treat ... more »
  • Columns

    • Off-Label Promotion Under Scrutiny by DOJ
    • Peter Spivack
    • In a continuing shift of enforcement strategy, the US Department of Justice (DOJ) has firmly taken control of off-label use allegations against pharmaceutical, biotechnology, and medical device manufacturers Various US attorneys’ offices around the country and especially in Washington, DC, ... more »
    • Adults Now Drive Growth of Vaccine Market
    • Bruce Carlson
    • For much of the 20th century, vaccines were a pharmaceutical success story largely associated with children Aggressive immunization programs eradicated polio and smallpox in developed nations and nearly eliminated mumps, pertussis, measles, and other diseases While immunization of the young ... more »
    • Dispersive Raman Spectroscopy Utilization
    • Nesredin Mussa
      Benjamin Locwin
    • Therapeutic protein characterization is a key requirement during the development and manufacturing of biopharmaceuticals It calls for techniques that are capable of deciphering the physical, biochemical, and biological characteristics of the product Protein conformational analysis (eg, secondary structure) is an ... more »