Leading the Way in Life Science Technologies

GEN Exclusives

More »

March 15, Vol. 28, No. 6

  • Feature Articles

    • Protein Microarray Uses Abound
    • Vicki Glaser
    • High-throughput proteomics using microarray-based technology and proteome chips is accelerating protein-biomarker discovery for research and diagnostic applications Researchers are using protein microarrays to profile protein expression in normal and diseased human cells, model organisms, and infectious microbes Technology advances and ... more »
    • Paucity of Biopharma Approvals Raises Alarm
    • Ronald Rader
    • FDA pharmaceutical approvals in recent years, particularly in 2007, have noticeably decreased Typically, coverage of declining FDA approvals has concentrated on pharmaceuticals in general or those regulated as drugs This article reviews 2006 and 2007 approvals of new biopharmaceutical treatments ... more »
    • Fragment-Based Approach Increases Leads
    • Elizabeth Lipp
    • Researchers are increasingly relying upon fragment-based lead discovery in their search for novel and effective drug candidates The approach utilizes a number of complementary technologies, with crystallography and structure-based drug design being two of these key techniques Last month, “Fragment-Based Lead ... more »
    • Surmounting Small Molecule Challenges
    • Nina Flanagan
    • Companies are developing new platforms to enhance their small molecule discovery efforts and, in turn, the molecules themselves This is due in part to increased pressure to develop new drugs With an estimated $20 billion of brand-name drugs going off ... more »
    • Getting More Out of Poor RNA Samples
    • Kathy Liszewski
    • Analysis of RNA provides the gateway to deciphering cells’ intricate workings Such information is critical for dissecting gene expression, biomarker analysis, and responses to therapeutics Dealing with RNA, however, can be tricky Degradation, limited amounts of sample, and newly emerging ... more »
    • Applications Broaden for Epitope Mapping
    • K. John Morrow Jr.
    • Epitope mapping, initially a basic-science tool for understanding the 3-D interactions between antigens and antibodies, is now being extensively employed to develop new therapeutics In vaccine technology, especially, scientists in academia and biotech firms have mobilized epitope discovery based on ... more »
  • Columns

    • Designing Improved Humans
    • Henry I. Miller, M.D.
    • The well-publicized use by athletes of performance-enhancing drugs including androgenic steroids and human growth hormone has gotten more people than ever before thinking and talking about the subject But the issue is neither new nor limited to a small number ... more »
    • Cellectar’s 3-Step Process to Target Tumors
    • Carol Potera
    • Cellectar , an early-stage oncology company, is banking on its radiopharmaceutical technology that combines lipid-like phospholipid ethers (PLE) with radioisotopes of iodine to seek out and destroy solid tumors and monitor the success of treatment Not surprisingly, the firm’s ... more »
    • Monogram Enters Theranostic Market
    • Querida Anderson
    • The advent of personalized medicine seems to have been upon us for a while now Many wonder whether the buzz surpasses the reality The scant number of individualized therapies and molecular diagnostics and prognostics on the market after decades of ... more »
    • Growth Foreseen for Ophthalmology Sector
    • Hermann Mucke
    • The market for prescription ophthalmological therapeutics will experience considerable and consistent growth throughout the next 10 years as demographic changes and lifestyle factors drive the need for developing safe and effective therapies for eye disorders... more »
    • Fermentas Learned Fast How to Go Global
    • Ilene Schneider
    • Founded as part of the former Institute of Applied Enzymology, a genetic research center established and funded by the Soviet government but located in Vilnius, Lithuania, Fermentas ’ original purpose was to develop tools for molecular biology at a time ... more »
  • Tutorials

    • Fine-Tuning Compound Safety Assessments
    • Richard Brennan
    • The significant failure rate of compounds entering clinical trials, due in large part to safety and efficacy concerns, has led the pharmaceutical industry to invest heavily in new technologies and to integrate safety assessment into the discovery and development pipeline ... more »
    • Machine Vision Improves HTS Quality Control
    • Jason Cassaday
    • Machine vision is the art of using computer-controlled cameras to maintain high levels of quality control in industrial processes In manufacturing, parts produced are often automatically imaged and analyzed to determine if the product produced is acceptable Often, feedback is ... more »
    • Metabolic Monitoring Enhances Production
    • Bo Xu
      Jens Gram
    • Astandardized approach for using process metabolic monitoring for enhancing microbial production of recombinant proteins is described in this tutorial by CMC Biopharmaceuticals Implementation is based on readily available equipment such as off-gas composition analyzers used in new ways as a ... more »