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May 1, Vol. 26, No. 9

  • Feature Articles

    • Advice on How to Survive the Taq Wars
    • As the engine that fuels the polymerase chain reaction (PCR)&#8212one of the most important inventions in molecular biology&#8212Taq DNA polymerase has transformed how life science research is conducted This powerful technique for DNA amplification relies on the amazing processivity of ... more »
    • ADMETox Improves Drug Discovery Rates
    • ADMETox profiling has assumed centerstage in the drug discovery process since the late 1990s ADMETox studies map the absorption, distribution, metabolism, excretion, and toxicity readouts of drugs or drug compounds in the context of the human body... more »
    • Systems-Based Approach Gaining Ground
    • Angelo DePalma
    • Biologys status as the engine of drug discovery is hardly ever questioned today, but it was not always so For the first century of the modern pharmaceutical age, chemists were expected to make educated guesses, often with little input from ... more »
    • Fragment-Based Drug Design Optimizes Hits
    • Fragment-based drug design is a new approach that has been successfully applied to challenging targets, such as protein-protein interactions While 3-D protein structures have been used in drug discovery for many years now, fragment-based drug design uses x-ray crystallography or ... more »
    • Utilizing Metabolic Profiling in Discovery
    • Recent advances in technology are bringing metabolic profiling to the forefront of drug discovery Although a lot of existing technology has been adapted for this field, researchers are developing unique methods to provide more qualitative and quantitative information In addition, ... more »
    • Pittcon 2006 Launches and Highlights
    • At the 57th &#8220Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (Pittcon)&#8220, held recently in Orlando, the focus of new product and service launches was on meeting customers demands and adjusting to the realities of the life science market Seamless ... more »
    • Surviving the Treacherous Transgenics Path
    • The production of therapeutic proteins in transgenic animals and plants seemed like a slam-dunk about a decade ago The potential benefits of transgenics when compared with traditional cell culture or fermentation are well known Nevertheless, no human therapeutic produced in ... more »
    • Navigating the Bench to Bedside Journey
    • The field of translational medicine is witnessing rapid maturation as companies focus their efforts on streamlining the passage of drug leads from the bench, through clinical trials, and ultimately to the bedside In contrast to traditional approaches to early drug ... more »
  • Columns

    • Brave New World of Patents and Pricing
    • Not long ago, even a me-too drug could expect pricing freedom through its patent life Today, we complain about poor R&D productivity, but this dearth of opportunities invites overnight imitators for the handful of successes that the new science has ... more »
    • Source MDx Advances Molecular Medicine
    • The new molecular diagnostic tools created at Source MDx (wwwsourcemdxcom) in Boulder, CO, are bringing personalized medicine closer to reality and advancing the new field of theranostics, or companion diagnostics Source reportedly holds the first-known intellectual property claim for a ... more »
    • Nanotechnology in Global Security and Economics
    • As with biotechnology, there is a global race to develop nanotechnology, the science of the very small Nanotech is estimated to be a $1-trillion industry within five to 10 years, compared to biotechs current worldwide revenue of $55 billion Given ... more »
    • Analysis of a Patent Applicant's Obligations
    • Patent applicants and their attorneys are charged with a duty of candor and good faith in their dealings with the US Patent Office In this regard, they have an obligation to make the Patent Office aware of any reference or ... more »
  • Tutorials

    • Surface Treatments for Fastidious Cells
    • Many factors contribute to the success of in vitro cell growth Although the characteristics of the cell and the media used play a critical role in this success, surface chemistry (ie, cell-to-surface interaction) must also be considered... more »
    • Detecting MD-Associated Gene Variants
    • One reason that researchers do not always find specific DNA sequence variations in genes associated with muscular dystrophy (MD) is that they lack a reliable and cost-effective assay to detect point mutations in these genes That problem may soon be ... more »
    • New Platform for Producing Viral Vaccines
    • Many human and animal vaccines currently being developed are produced in eggs or primary chicken embryonic fibroblasts (CEFs) Eggs and CEFs are used to manufacture both human and animal health vaccines These processes have changed little in more than 60 ... more »