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June 1, Vol. 38, No. 11

  • Feature Articles

    • Gene Therapy Ever More Common for Rare Disorders
    • Brandon May
    • Resurgent across the biomedical engineering and clinical trial landscape, gene-therapy owes its new vitality to a better understanding of rare diseases, the discovery of new gene delivery vectors, and the development of site-specific genome editing technology Already pushing up new ... more »
    • HPLC Summit Offers Expansive Biomolecular Views
    • Vicki Glaser
    • Large, complex, and subtly heterogeneous, biopharmaceutical compounds present countless separation challenges Fortunately, these challenges are neither so great nor so many as to daunt the biopharmaceutical industry’s separation specialists, the analysts who make use of high-performance liquid chromatography (HPLC)... more »
    • Supplement: CRISPR
    • John Sterling
      Kevin Davies
    • You know biotechnology is capturing the public’s imagination when it becomes the premise of a Hollywood blockbuster In “Rampage,” one of the big movie releases this spring, Dwayne “The Rock” Johnson saves mankind from the havoc wreaked by a trio of ... more »
    • Supplement: CRISPR Enters the Clinic
    • Josh P. Roberts
    • The CRISPR revolution—which is bringing even nonexperts the ability to rapidly edit genetic material with pinpoint precision—is beginning to infiltrate the clinic Standing on the shoulders of gene therapy , cell therapy, and bone marrow transplantation, several groups in the ... more »
    • Supplement: CRISPR in the Courthouse
    • Given the exciting applications of CRISPR in fields ranging from gene therapy to genetically modified foods, there has naturally been intense scrutiny of the ongoing dispute regarding the discovery and patenting of CRISPR gene editing technology No one has covered ... more »
  • Tutorials

    • Host-Cell Protein Impurity Analysis
    • Ken Hoffman
    • The terms “process-specific” and “generic” are commonly used in scientific publications and regulatory guidelines in reference to host cell protein (HCP) analysis of recombinant biopharmaceuticals The terminology distinction is based on theoretical concerns that generic assays could potentially fail to ... more »
    • Supplement: Analyzing CRISPR Editing Results
    • Jessica Roginsky
    • CRISPR-based genome engineering revolutionized the gene-editing field by making experimental workflows considerably easier, faster, and more efficient than previous methods Still, generating reliable results from CRISPR-editing data requires the help of robust software tools... more »
  • Sponsored Content

    • Streamlining the Peptide Synthesis Process
    • CEM provides microwave instrumentation for researchers involved in analytical and synthetic chemistry Major application areas include acid digestion for elemental analysis, compositional testing of food products, peptide synthesis, and chemical synthesis... more »