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March 15, Vol. 36, No. 6

  • Feature Articles

    • Gene Editing Casts a Wide Net
    • Kate Marusina
    • Genome editing, a much-desired means of accomplishing gene knockout, gene activation, and other tasks, once seemed just beyond the reach of most research scientists and drug developers But that was before the advent of CRISPR technology, an easy, versatile, and dependable ... more »
    • Biotech Embroiders Intricate Glycopatterns
    • Angelo DePalma
    • Through its association with monoclonal antibody quality, safety, and efficacy, glycosylation remains a hot issue for biotech Accordingly, improving glycosylation is a priority for companies such as Agilent Technologies, which has undertaken several initiatives to improve glycan analysis within the ... more »
    • Flow Cytometry Crystal Gazing
    • Kathy Liszewski
    • Although flow cytometry is a workhorse technology that has been around for more than 50 years, it still shows a lively gait In fact, flow cytometry is about to break into a gallop, spurred by technological advances such as the integration ... more »
    • Dissecting Gene Expression Networks
    • Richard A. Stein
    • Efforts to interrogate the link between genotypes and phenotypes catalyzed some of the fundamental advances in science Novel tools and frameworks to study gene expression and its regulation have been at the core of these developments By revealing intricate details about biological systems, ... more »
  • Tutorials

    • Overcoming the Roadblocks to Successful T-Cell I...
    • Andrew Ball
    • Cell-based therapeutics, such as CAR-T cancer therapies, are poised to transform 21st century medical care These innovative medicines require highly specific isolation and purification of large numbers of viable, functional cells, a process that is often technically complex and cost-prohibitive ... more »
    • Visualizing Noncoding RNA
    • Xiao-Jun Ma
    • The significance of noncoding RNA is becoming increasingly recognized as new classes involved in genetic regulatory control and diverse cellular activities are being uncovered on a regular basis Discovering the world of noncoding RNAs has already unlocked many secrets about ... more »
    • Analysis of PTMs via Capillary LC Coupled with H...
    • Greg Kilby
    • Recombinant monoclonal antibodies (mAbs) have been among the most successful pharmaceutical products Global sales for mAbs reached nearly $75 billion in 2013, representing approximately one-half of sales for all biopharmaceuticals mAbs comprise about 40% of development-stage biosimilars, according to McKinsey ... more »