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June 1, Vol. 35, No. 11

  • Feature Articles

    • Big Sequencing Beclouds Big Data
    • MaryAnn Labant
    • According to Illumina, next-generation sequencing data volume has doubled every year since 2007, representing over a 1,000-fold increase in the amount of data that needs to be processed Add in proteomics, metabolomics, medical records, and other information, and it is ... more »
    • GEN Roundup on Transfection Techniques
    • Transfection is the definitive method for deliberately introducing DNA or RNA into cells, most often for gene therapy purposes There are several technical approaches available for performing a transfection experiment either in vitro or in vivo... more »
    • Easing Bioprocess Bottlenecks
    • Angelo DePalma
    • Originally conceived as being analogous to what chemists would call a slow step in a chemical reaction, bioprocess bottlenecks are still primarily viewed as any unit operation that slows down the overall process In practical terms, the definition may be ... more »
  • Tutorials

    • Biosensors for Cytotoxicity Testing
    • Angela L. Huang, Ph.D.
    • Cellular energy production depends on mitochondrial integrity and function Mitochondrial dysfunction has been shown to alter the cell cycle, metabolism, cell viability, gene regulation, and other key aspects of cellular growth and survival In cancer studies, glycolysis persists to build ... more »
    • Chromatography Automation
    • Karl E. Milius
    • For chromatographers, maintaining sample integrity is essential in order to obtain ultimate sample separation and analysis Today, more and more operations within the lab are moving to automated and semi-automated systems When high-throughput autosamplers and instruments that are compatible with ... more »
    • From Particles to Columns and Processes
    • Julio Cabrera
    • The influence of particle and pore size has been recognized since the publication of the first theories of chromatography Ideally, and in very general terms, a process should maximize the contact between the chromatographic media and the biological molecule being ... more »