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June 1, Vol. 33, No. 11

  • Feature Articles

    • Getting Creative with Mass Spec
    • Sridhar Nadamuni
    • Innovations in instrumentation and application of mass spectrometry offer solutions to routine analytical challenges across a range of areas including glycoproteomics, homeland security, forensics, environmental analysis, and the food industry, among others... more »
    • Deciphering the Mysteries in Lipid Biology
    • Kate Marusina
    • Lipids constitute the majority of metabolites in plasma They stand out because of their structural diversity and the sheer number of molecular species In-depth analysis by the consortium called LIPID Metabolites And Pathways Strategy (LIPID MAPS) revealed almost 600 distinct ... more »
    • Pushing the Boundaries in Chromatography
    • Angelo DePalma
    • In 1964, University of Utah Chemistry Professor J Calvin Giddings enunciated a theoretical platform that would provide liquid chromatography (LC) with resolving power equivalent to that of gas chromatography (GC) “Unified separation science” became a buzzword soon after... more »
    • Lights, Camera, and Lots of Cellular Action
    • MaryAnn Labant
    • Innovations in live-cell imaging are reshaping scientific paradigms, opening the door to new approaches for scientific inquiry and opportunities for predictive modeling Emerging technologies allow more in-depth molecular and cellular data collection from living cells and tissues... more »
  • Columns

    • Acquired Drug Resistance in Cancer
    • Patricia Fitzpatrick Dimond
    • Oncologists continually face the challenge of matching the right therapeutic regimen with the right patient, balancing relative benefit with risk to achieve the most successful outcome But they say, in current clinical practice, physicians and patients are “often disappointed” by ... more »
    • Don’t Let Fraud Ruin Your Deal
    • Mark C. Goodman
    • Issues of fraud have always been part of mergers and acquisitions It was largely because of such issues that the concept of due diligence came into being However, such issues have a renewed importance in today’s global economy, where deals ... more »
    • Capturing CTCs for Molecular Analysis
    • Tracy Vence
    • Scientists have long recognized the potential of circulating tumor cells (CTCs) as diagnostic and prognostic indicators Recent research has shown CTCs derived from whole blood can even have therapeutic implications, directing oncologists to choose tumor-specific treatments But these cells are ... more »
    • Vaccine Advances Drive Differentiation
    • Gail Dutton
    • The vaccines market is being driven by new antigens, delivery mechanisms, manufacturing methods, targets, and markets As new entrants near commercialization, industry consolidation is likely, particularly in the adult vaccine segment In the seasonal and pandemic vaccine market, competition remains ... more »
    • DNA Sequencing: Coming to a Clinic Near You
    • This April marked the 10-year anniversary of the release of the first human genome reference sequence, an epic milestone in the annals of medical science The use of “first-generation sequencing” required over a decade and almost $3 billion Today’s next-generation ... more »