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November 15, Vol. 30, No. 20

  • Feature Articles

    • Tandem MS Zooms In on Glycosylation
    • Vicki Glaser
    • Characterization of the carbohydrate portion of glycoproteins in a high-throughput, cost-efficient manner presents myriad technological challenges Unlike the linear peptide components of these molecules, carbohydrates can be complex, branched structures containing monomeric units that may link an oligosaccharide to a ... more »
    • Microarrays & Sequencing Assume Supporting Roles
    • Richard A. Stein
    • Recent decades have marked exciting times for biological sciences Since the 1977 milestone publication of the first genome, that of the single-stranded bacteriophage ΦX174, new methodologies that culminated with the implementation of next- and next-next generation sequencing platforms and the ... more »
    • Encouraging Suppliers to Communicate
    • Gail Dutton
    • Last year, when ATM and cash register manufacturer NCR moved its European manufacturing plants to the US, one of its early efforts was to gather 260 of its suppliers together at Georgia Tech to leverage their knowledge “It was fantastic ... more »
    • Capitalizing on Cell-Signaling Advances
    • Patricia Fitzpatrick Dimond
    • The development and clinical application of drugs that target intracellular signal-transduction pathways has profoundly changed the treatment of human cancers Tools enabling complex pathway analysis, particularly those that can identify critical regulatory post-translational modifications, continue to facilitate discovery of novel ... more »
    • Flow Cytometry Expands Application Range
    • Catherine Shaffer
    • Flow cytometry is and always has been a multiparametric technology Increasingly simultaneous and correlated measurements can be used to provide greater detail about the phenotype of cellular subpopulations Clinical laboratories now routinely employ 5- or 6-color flow cytometry, while research ... more »
    • Impact of Single-Use Biomanufacturing Systems
    • Tony Hitchcock
    • The development of manufacturing processes and the production of clinical material for new drug candidates is a decisive phase in pharmaceutical development Decisions made during the early stages of process development have a lasting impact on the manufacturing route for ... more »
    • Asia Emerging as Healthcare Destination
    • Robert Yuan, Ph.D.
    • Outsourcing of manufacturing and services is a reality of today’s globalization Medical treatment appears to be next on the outsourcing list as we are now seeing vigorous growth in the number of patients traveling across national borders for healthcare purposes ... more »
  • Columns

    • Solving the Next-Gen Sequencing Data Crunch
    • Carol Potera
    • The foundation for Eureka Genomics  was laid several years ago during a meeting sponsored by the US Department of Homeland Security Researchers were demonstrating their inventions when one  presenter, Yuriy Fofanov, PhD, director of bioinformatics at the University of Houston, ... more »
    • Extending the Range of miRNA Technology
    • Carol Potera
    • Most biotechnology startups are built around a technology platform invented in a university laboratory or as a spinoff of another company Chris Hillier, PhD, however, founded Sistemic in 2008 to fill an unmet market need and he created the miRNA ... more »
    • Bringing Hand-Me-Downs to Science Labs
    • Christianne Bird
    • Among the plethora of life science tool companies, there exists a market for used and refurbished equipment that follows a very different business model and contains unique dynamics compared with new product sales Nevertheless, it is a quickly growing market ... more »