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April 1, Vol. 30, No. 7

  • Feature Articles

    • Mass Spec Central to Metabolomics
    • K. John Morrow Jr.
    • The emerging field of metabolomics would be hobbled by irresolvable technical challenges were it not for the expanding availability of user-friendly and affordable mass spec instruments A German Research Center for Environmental Health conference, “Metabolomics & More—the Impact of Metabolomics ... more »
    • Cell Culture Moving Past Previous Technical Limi...
    • Gail Dutton
    • Spodoptera frugiperda (the fall armyworm caterpillar) and the duck are gradually replacing the chicken as the creature of choice for vaccine production New cell-culture techniques and, particularly, recombinant technologies, are bringing faster production cycles and higher purity yields, according ... more »
    • RNAi Therapeutics Gaining Ground
    • Kathy Liszewski
    • Inappropriate gene activity is being linked to a growing number of diseases The ability to modulate or silence such activity via RNA interference (RNAi) technologies could revolutionize the way we treat disease RNAi, as a new class of drugs, has ... more »
    • Hydroxyapatite for Biomolecule Purification
    • Pete Gagnon
    • Just a decade ago, experimental work by Guerrier, Flayeux, and Boschetti demonstrated the ability of sodium chloride (NaCl) gradients on hydroxyapatite (HA) to remove aggregates from IgG preparations This approach has since proven effective with the majority of IgG monoclonal ... more »
    • Aseptic Filling Adjusting to New Paradigm
    • Angelo DePalma
    • Aseptic filling—the final step before packaging parenteral small molecule and biotherapeutic drugs—represents one of the most technologically innovative and dynamic areas of downstream operations Filling operations are changing in response to larger industry trends, explains Peter Soelkner, managing director of ... more »
    • Cancer Diagnostics Seek to Fulfill Promise
    • Elizabeth Lipp
    • Personalized medicine, the application of genomic and molecular data to better target disease states, has been defined as a novel therapeutic concept for over a decade At CHI’s “Molecular Medicine Tri Conference,” held recently in San Francisco, presenters demonstrated how ... more »