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December 1, Vol. 37, No. 21
  • Feature Articles

    • Viral Safety Copes with Complexity
    • Angelo DePalma
    • If dealing with viral contamination seems like opening a can of worms, try not dealing with it Yes, viral contamination occurs infrequently, but when it does occur, the consequences can be severe Viral contamination incidents can shut down production facilities ... more »
    • Turning Cell Signaling against Cancer
    • Richard A. Stein
    • A key characteristic shared by all living cells is their ability to communicate with other cells and with their environment This process, accomplished by intricate cell-cell and cell-signaling interaction networks, is critical during development, homeostasis, and disease pathogenesis In recent ... more »
    • Supplement: Best of CRISPR 2017
    • Kevin Davies
      John Sterling
    • One sweltering summer afternoon in 2003, a vacationing Spanish microbiologist named Francisco Mojica told his wife he was going to seek refuge in his air-conditioned lab at the University of Alicante For years, Mojica had been puzzling over the putative ... more »
    • Supplement: Applications of Novel CRISPR Tools
    • Using a CRISPR-based genetic screen, Cellecta recently identified, for a client, a class of proteins responsible for regulating gene expression of a genetic element present in the 5′-untranslated region (5′-UTR) of a gene involved in a specific disease indication... more »
  • Tutorials

    • MALDI-MS Detection Schemes Hasten Drug Developme...
    • Rohan Thakur
    • Over the last few decades, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has proven its usefulness and robustness in many applications Recent innovations in MALDI-MS utilize advances in two detection schemes being applied to accelerate preclinical drug discovery: one in ultra-high-throughput ... more »
    • Pepide-Based Delivery of Recombinant Proteins an...
    • James E. Dixon
      Robin Quirk
    • Successful regenerative medicine strategies often rely on exquisite control of the biological microenvironment and supplementation with extrinsic therapeutic molecules to direct cellular behavior 1,2 These macromolecules trigger intracellular signal transduction pathways, with complex cross-talk between the cascades and eventual programming ... more »