In this video, Rajarshi Guha Ph.D., an informatics research scientist in the Division of Pre-Clinical Innovation at the National Center for Advancing Translational Sciences (NCATS) within the National Institutes of Health (NIH), provides an in-depth look at Pharos, the user interface for the Knowledge Management Center (KMC) knowledgebase. The KMC was created to aggregate and integrate heterogeneous data sources and data types creating a centralized location for information about all protein targets identified as part of the druggable genome. Dr. Guha will provide an overview of the data sources and types made available via Pharos and then describe the architecture of the system and its integration with KMC & external resources—highlighting the rich search facilities that enable a user to drill down to relevant subsets of data. Finally, Dr. Guha will describe how to use the Pharos interface for prioritizing understudied targets by computing the similarity of their knowledge availability profiles with that of well-studied targets. This video is from a recent presentation as part of the Big Data to Knowledge-Library of Integrated Network-based Cellular Signatures (BD2K-LINCS) programs.