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September 4, 2008

Tocris to Provide Gefitinib for Preclinical Cancer Research

  • Tocris Bioscience signed an exclusive deal with AstraZeneca to supply Gefitinib (also known as Iressa™ and ZD1839) to preclinical researchers working on the mechanisms underlying cancer development. Strict conditions have been imposed by AstraZeneca to ensure that it is not used in human studies, notes Duncan Tocris.

    For the first time, scientists will be able to buy authentic, fully licensed, nonformulated Gefitinib as an off-the shelf product for use in biological research, according to Tocris.

    Gefitinib targets and blocks the activity of the EGFR-TK (epidermal growth factor tyrosine kinase), an enzyme that regulates intracellular signaling pathways implicated in cancer cell proliferation and survival. It is approved for the treatment of advanced non-small-cell lung cancer (NSCLC) in 36 countries.