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May 15, 2018 (Vol. 38, No. 10)

With Digital PCR, the Rare Becomes Routine

Applications Which Bring Rare Events to Light Are Proliferating

  • Even standard polymerase chain reaction ( PCR ) technology should, in principle, boost weak mutant signals so that they may emerge from all the genomic noise emitted by wild-type sequences. Yet standard PCR , for all its sequence-amplifying and signal-boosting powers, is still a qualitative technique.  That is, ...

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