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April 15, 2012 (Vol. 32, No. 8)

Use of siRNA in Therapeutic Arena on the Upswing

  • In contrast to miRNAs, siRNAs are usually perfectly complementary to their targets. They are thus very effective at eliminating gene expression. For this reason, synthetic siRNAs have been generated for a number of therapeutic uses. But of course, there are hurdles: stability, potency, off-target effects, and efficient delivery of ...

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