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April 01, 2011 (Vol. 31, No. 7)

Targeting Viruses Before They Enter the Body

Mymetics Seeks to Prevent Infection with Vaccines that Induce IgA Antibodies at the Mucosal Level

  • Strong Proof-of-Concept Evidence

    Blocking mucosal entry is proving highly promising, yet it is still a poorly investigated route. Mymetics scientists presented preclinical results obtained from research on macaques that were either immunized with MYMV101 or left nonimmunized. After repeated challenges with HIV, all the animals that were immunized both intramuscularly and intranasally remained uninfected, whereas 100% of the nonimmunized controls became infected.

    In contrast, when macaques were immunized only intramuscularly and not given the intranasal booster, just half of them were protected from HIV challenges. “Injections alone raise lower levels of immunity, and the intranasal application is needed to optimize mucosal immunity,” Martin explains.

    Next, a Phase I trial involving 24 women showed that the vaccine induced not only serum antibodies but also mucosal antibodies in the genital and intestinal tracts in most of the volunteers. In the past 25 years, few other HIV vaccine candidates have elicited both blood and mucosal antibodies, Martin notes.

    Conducted at the Center for Vaccinology at the University of Ghent, Belgium, the women received two injections of the vaccine, followed by two doses given as a nasal spray. The preliminary results in macaques and humans “are an important validation of our work and approach.”

    In addition to HIV/AIDS, Mymetics has four other vaccines in the pipeline: influenza, respiratory syncytial virus (RSV), malaria, and herpes simplex virus (HSV). All are based on the virosome delivery technology, and with the exception of the malaria vaccine, stimulate mucosal immunity.

    Solvay Pharmaceuticals (now Abbott Pharmaceuticals) licensed the influenza vaccine, a totally intranasal application aimed at the elderly, and is starting Phase II testing. The RSV and HSV vaccines are in preclinical testing. The malaria vaccine completed a Phase Ib trial in Tanzania where it was well tolerated and triggered long-lasting antibody responses. Mymetics plans to develop its vaccines through Phase II trials, then license them to pharmaceutical companies.

    The vaccine world has viewed Mymetics’ mucosal approach with skepticism. However, “when the macaque results were made public, it became difficult to ignore that our approach is valid,” says Ronald Kempers, CFO. The Gates Foundation, National Institutes of Health and other international agencies are watching the progress of the Mymetics platform.

    The lack of popularity of mucosal vaccines stems partly from a failed influenza vaccine given intranasally that was marketed by Berna. Because of serious side effects, such as facial pain, it was withdrawn from the market. “This discouraged others from making nasal mucosal vaccines,” says Martin.

    Since then, scientists at Mymetics learned that the adverse effects of the Berna vaccine were due to an adjuvant, not the vaccine itself. “We do not need adjuvants with our virosomes, and we hope this makes people more comfortable with the idea of mucosal vaccines.”

    It was also assumed that a mucosal vaccine had to be given at the primary site of infection, such as the respiratory tract to prevent influenza. The results of the Phase I trial proved otherwise. “When given as an intranasal application, mucosal antibodies were induced vaginally and rectally,” says Martin. He hopes that the results will attract new funding opportunities.

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