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February 01, 2009 (Vol. 29, No. 3)

Targeting Post-Translational Modifications

Glycosylation, in Particular, Will Play a Critical Role in the Approval of Biosimilars

  • Post-translational modifications (PTM)—chemical transformations that occur after a protein’s translation from RNA—include numerous changes, some well known and others quite obscure. Modifications based on the addition of molecules or functional groups are the most apparent and probably the most significant in terms of biological activity. These include acylation/deacylation, amidation, ...

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