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November 15, 2010 (Vol. 30, No. 20)

Tandem MS Zooms In on Glycosylation

Conventional Methods Are Inadequate When It Comes to Quantitative and Structural Analysis

  • Characterization of the carbohydrate portion of glycoproteins in a high-throughput, cost-efficient manner presents myriad technological challenges. Unlike the linear peptide components of these molecules, carbohydrates can be complex, branched structures containing monomeric units that may link an oligosaccharide to a protein at more than one site. Furthermore, a ...

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