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June 15, 2012 (Vol. 32, No. 12)

Taming Difficult to Express Proteins

  • In small molecule drug development, it is often said that the low-hanging fruit has already been harvested. Most structures that are chemically accessible, manufacturable, and druggable have already been considered. Somewhat analogously, the leading edge in biologics development are proteins that for one reason or other present development ...

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