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March 01, 2009 (Vol. 29, No. 5)

Stem Cell Funding Roadblock

Dickey Amendment Is an Antiquated Obstacle that Impedes Valuable Research

  • When President Bush assumed office, the human embryonic stem cell revolution was primed to launch. The outgoing Clinton administration directed the NIH to prepare comprehensive rules to govern the nascent field of discovery, with funding to follow. Eight years later, we have no comprehensive federal guidelines. Each funding authority has its own set of rules and funding has been relatively minimal, especially when compared to the annual $28 billion NIH budget.

    President Bush ordered a hold on the NIH guidelines and purportedly studied the situation. On August 9, 2001, in a surprise Crawford announcement, President Bush actually narrowed the Clinton plan, permitting federal funding only to those stem cell lines created on or before that arbitrary date (August 9, 2001) and time (9:00 PM). Rather than making the pronouncement of this important public health policy by formal order, it was delivered by television address and a media advisory.

    Twisting logic like a pretzel, President Bush premised his views that in vitro blastocysts were “human life” and to continue funding on stem cell lines created after his August 9 pronouncement would somehow induce derivation of new lines, thereby making the federal government complicit in the destruction of embryos. In the case of the few existing lines available for funding, by Bushian logic, the terrible deed had already been done and limited funding could proceed on those lines only.

    Before considering President Obama’s plans, it serves us well to examine the legislative foundation that produced such an unsatisfactory policy. The actual rate-limiting statute is the Dickey Amendment, a largely overlooked legislative funding roadblock that is a perennial appropriations rider to the NIH budget. It is what Harvard philosopher Louis Guenin aptly describes as the “elephant in the room.”

    Named after its sponsor, former Arkansas Congressman Jay Dickey, the Dickey Amendment was enacted in 1995. It precludes using federal money for the creation, destruction, or endangerment of human embryos for research purposes. It is a blockade for funding research on embryos discarded from in vitro fertilization procedures to derive new cell lines or somatic cell nuclear transfer. It essentially codifies the viewpoint that embryo research is a moral transgression.

    Each time the Dickey rider comes before Congress, it is enacted without debate. It was the law before the discovery of human embryonic stem cells in 1998 and is a throwback to the roiling abortion debate in America. In the Bush years, there was no appetite to directly challenge Dickey.

    If the Dickey Amendment prohibits NIH funding endangering embryos, how can NIH fund any of this research? By literal reading of the Dickey Amendment, there is a loophole that would allow funding in narrow circumstances. Where the actual derivation of a stem cell line is accomplished without NIH monies, the resulting cell line could be eligible for federal funding. To date, every policy-maker seemingly worships at the Dickey altar and every funding scheme is designed to thread this narrow hole in the needle.

    The absurdity of the rule is evidenced in the frustrations of research institutions to comply with current federal policy, or risk losing all of their NIH grants. Those institutions deriving new cell lines or undertaking research on “nonpresidential” lines are compelled to construct separate laboratories and manage complex bookkeeping systems to keep the NIH grant money separate. It’s a real mess.

    President Obama will most certainly deliver the long-promised executive order lifting the Bush restrictions and Congress will subsequently deliver a bill making the new funding permanent. The likely statutory vehicle will be the bipartisan-supported Stem Cell Research Enhancement Act, also called the Castle-DeGette bill, a piece of legislation twice vetoed by President Bush, which would allow NIH funding on more recently derived stem cell lines.

    However, that bill, as presently drawn, does not repeal Dickey, which seemingly remains sacrosanct. It will take courage and farsightedness by Congressional stem cell proponents to do away with this pernicious restriction on potentially lifesaving research.

Posted 3/6/2009 by Missing the mark

In his passion to vilify those who disagree with him, Dr Siegel fails to address the most important point, which is that science is amoral, so the lines drawn between science that should be done and science that shouldn't is a moral choice, not a scientific one. In this case, it is based on one's moral philosophy of the nature of the embryo, and whether human embryos are scientific reagents. Dr Siegel obviously disagrees with the view of "social conservatives", but his diatribe adds nothing to further our national discussion of this issue.

Posted 3/2/2009 by CEO of Hunt down the God Cons

Bush's well funded GOP Base-The Religious Rights are hoping the Dickey Amendment will derail the Obama Stem Cell Express.


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