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March 15, 2018 (Vol. 38, No. 6)

RNAi Therapeutics: To the Liver ... and Beyond

RNAi Therapy Components Are Surviving Degradation, Staying Potent, and Reaching More Targets Than Ever

  • As a means of perturbing gene expression—and avoiding manipulation of the genome—RNA interference (RNAi) has distinct advantages. RNAi, it must be said, is hardly unique in its ability to target individual genes. This ability is shared by RNAi with CRISPR inteference (CRISPRi), which may provide even better gene targeting ...

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