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July 01, 2008 (Vol. 28, No. 13)

Reducing Downstream Purification Costs

Controlling the Economics of These Activities Is Not As Hard As It Sounds

  • Over the years, bioprocessors could, at various times, debate whether upstream or downstream operations represented the slow step, relatively speaking, of therapeutic protein production. Now, with protein titers rising inexorably, purification is likely to remain rate-limiting, for a given facility layout, for a very long time. Cost considerations ...

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