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November 15, 2014 (Vol. 34, No. 20)

Ready, Aim, CRISPR (or RNAi)

When targeting genes, drug developers may opt for knockdown via CRISPR or silencing via RNAi. These weapons, however, may fit different battle plans.

  • Recent progress in probing gene function via the RNAi and CRISPR methods were a strong theme of the Discovery On Target conference, which took place last month in Boston. Both methods enable researchers to impair the function of a targeted gene. With RNAi (short for RNA interference), molecules ...

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