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January 01, 2011 (Vol. 31, No. 1)

Power in Numbers for Cancer Biomarkers

Developing Effective Targeted Therapies Requires Elucidation of Multigene Signatures

  • It is no longer believed that dysregulation of limited amounts of oncogenes or tumor-suppressor genes causes cancer. Cancer cells show aberrant regulation of many other genes directly or indirectly involved in carcinogenesis and tumor progression. Therefore, observation of a single protein or gene is no longer meaningful by itself: ...

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