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April 01, 2018 (Vol. 38, No. 7)

Peptide Therapeutics Near the Sweetest Spots

Advantages May Place Peptides Ahead of Small-Molecule Drugs

  • Peptide therapeutics would seem to occupy a sweet spot between small molecules and biologics. Small molecules, which represent the majority of clinical drugs, preferentially bind hydrophobic pockets or cavities, but targeting them to protein interfaces that are large or shallow, or contain combinations of polar and apolar residues, is ...

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