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September 01, 2008 (Vol. 28, No. 15)

Next-Generation Sequencing Update

With the Advent of Sophisticated Platforms, Genomes Can Be Sequenced in Record Time

  • About three decades ago, the Sanger and Maxam-Gilbert methods revolutionized the biomedical world. Sequencing of the 5,386-base bacteriophage PhiX174 in 1977 represented a memorable moment in science. About one thousand base pairs could be sequenced annually at the time, and relying on the same approach, completion of the ...

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