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June 01, 2011 (Vol. 31, No. 11)

Kinase Inhibitor Obstacles Falling

Structural Modeling and Improved Assays Propel Advances in Field

  • Protein kinases drive many critical cellular events including proliferation, metabolism, apoptosis, and differentiation. They catalyze the transfer of the terminal phosphate from ATP to tyrosine, serine, or threonine residues of the kinase itself or another protein substrate. Therapeutic inhibition of protein kinases has revolutionized the treatment of certain cancers. ...

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