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June 01, 2011 (Vol. 31, No. 11)

Getting Around Downstream Bottlenecks

A Variety of Total and Incremental Solutions Exist for Firms Not Averse to Change

  • Prevailing wisdom holds that upstream efficiencies cause downstream bottlenecks. Yet perceptions regarding bottlenecks, their sources, and how to deal with them differ widely. Downstream bottlenecks can occur at any step, particularly at innately slow steps like chromatography, or where pooling or hold-up are involved. Virus removal or inactivation, ...

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