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October 15, 2008 (Vol. 28, No. 18)

Fine-Tuning the Design of GPCR Therapeutics

Understanding Allosteric Modulation and Functional Selectivity Are Key Priorities

  • Bryan Roth, M.D., Ph.D., director of the National Institute of Mental Health’s psychoactive drug screening program at the University of North Carolina, suggests that the information printed in textbooks of pharmacology is “far from reality.” He is referring to recent discoveries about the incredible complexity of GPCR, the theme ...

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