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September 01, 2013 (Vol. 33, No. 15)

AAV Vectors for Infectious Diseases

University of Pennsylvania Gene Therapy Team Finds Applications in HIV, Flu, and Biothreats

  • The failure of the adenovirus Ad5 vaccine in the STEP study, halted in 2007, sparked renewed interest in developing antibody-based, rather than T-cell-based, vaccines against the AIDS virus. However, HIV evolves so rapidly that developing a vaccine formulation eliciting the necessary breadth of antibodies against the virus has ...

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