Candidates: Vaccine and antibody candidates


Types: Virus-Like Particle (VLP) vaccine combining Medicago’s recombinant Coronavirus Virus-Like Particles (CoVLPs) with GSK’s pandemic adjuvant system. The companies will manufacture the COVID-19 vaccine antigen through Medicago’s plant-based production platform, which uses the leaves of a plant as bioreactors to produce the S-spike protein which self-assemble into VLPs for use in the CoVLP vaccine candidate.

Medicago separately is also developing antibodies against SARS-CoV-2 through its plant-based technology platform in collaboration with Laval University’s Infectious Disease Research Centre headed by Gary Kobinger, PhD, whose lab developed a successful Ebola vaccine. That research is being funded in part by the Canadian Institutes for Health Research.

Status: GlaxoSmithKline joined Medicago on July 7 to announce a collaboration to develop Medicago’s CoVLP vaccine. The companies plan to start Phase I clinical testing in mid-July, and assess the safety and immunogenicity of three different dose levels of antigen combined with GSK’s pandemic adjuvant and in parallel with an adjuvant from another unnamed company, administered on a one- and two-dose vaccination schedule, given 21 days apart.

The companies said they aim to complete development and make the vaccine available in the first half of 2021, with approximately 100 million doses expected to be manufactured by the end of 2021. By the end of 2023, a large-scale facility under construction in Quebec City, Canada, that is expected to deliver up to 1 billion doses annually.

GSK and Medicago also agreed to evaluate expanding their collaboration to develop a post-pandemic vaccine COVID-19 candidate, “should the need arise based on the further development of COVID-19 after the pandemic,” and other infectious diseases.

Medicago and GSK noted that CoVLPs mimic the structure of the virus responsible for COVID-19 disease, allowing them to be recognized by the immune system—while reasoning that adding an adjuvant may boost immune response and reduce the amount of antigen required per dose, allowing more vaccine doses to be produced and therefore contributing to protect more people.

The Government of Canada announced March 23 that Medicago was among companies set to receive an unspecified amount of funding from the $192 million available for new, large-scale projects under the new Strategic Innovation Fund COVID-19 funding stream—part of the government’s $1 billion COVID-19 Response Fund. Two days earlier, the Government of Quebec awarded C$7 million (about $5 million) toward the company’s vaccine development effort.

Medicago said March 12 it successfully produced a coronavirus VLP 20 days after obtaining the SARS-CoV-2 gene—the first step in developing a vaccine for COVID-19. The vaccine will undergo preclinical testing for safety and efficacy, followed by human trials anticipated to start by summer (July/August) 2020.

COVID-19: 200 Candidates and Counting

To navigate through the >200 potential therapeutic and vaccine options for COVID-19, GEN has grouped the candidates into four broad categories based on their developmental and (where applicable) clinical progress:

FRONT RUNNER – the most promising therapeutics/vaccines based on clinical progress, favorable data or both.

DEFINITELY MAYBE – earlier phases with promising partners, or more advanced candidates in development that have generated uneven data

KEEPING AN EYE ON… – interesting technology, attracting notable partners, or both, but preliminary data.

TOO SOON TO TELL – longshots pending additional experimental and/or clinical data.

GEN has also tagged the most common treatment types:


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