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  Eli Lilly Plans $400M Manufacturing Expansion
  
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  Bioprocessing
  
  Gene Therapy Companies’ Demands Reshape CDMOs
  
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- November 2019 Vol. 39 No. 11
  
  Synthetic Biology Seizes New Ground in Healthcare
  
  November 2019 Vol. 39 No. 11
  
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  November 2019 Vol. 39 No. 11
  
  Protein-Protein Interactions Get a New Groove On
  
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  Biomarker Specialists Team Up, Run Up the Companion Diagnostics Score
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Home Translational Medicine Biomarkers

Biomarkers

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Biomarkers

Measuring Cancer’s Response to Treatment with a Liquid Biopsy Kit

At Left. A multiplexed pharmacodynamics assay was developed recently to assess immune checkpoint inhibitor–targeted CD8 activation and tumor colocalization in formalin-fixed paraffin-embedded tissues. The assay, which used oligo-conjugated antibodies supplied by Ultivue, achieved multiplex staining of CD8 (red), CD3z-pY142 (yellow), β-catenin (cyan), and Zap70-pY493 (not shown) on bead-activated CD3 cells from tissue spiked with interferon-γ-induced ACHN tumor cell lines. Staining of β-catenin allowed tumor cells to be differentiated from immune cells. Arrows point to CD8 cells that are CD3z-pY142+, indicating T-cell receptor activation.

Biomarkers

Biomarker Specialists Team Up, Run Up the Companion Diagnostics Score

Biomarkers

Synthetic Biomaterial Scaffold Could Serve as Early Cancer Diagnostic

Turning a dangerous toxin into a biosensor screenshot

Biomarkers

Aerolysin, a Toxin, Shows Promise as a Powerful Biosensor

Biomarkers

Methyl Group-Based Cancer Test Shows High Sensitivity and Specificity

Biomarkers

Prostate Cancer Screens Might Turn to Biomarkers in Semen

Biomarkers

Breathalyzer Sniffs Out Potential Cancer Immunotherapy Responders

Biomarkers

Cancer Biomarker Recognized in Methylated MicroRNA

Biomarkers

A Liquid Biopsy for Infectious Diseases?

Biomarkers

Liquid Biopsies Intensify Surveillance of ctDNA

Biomarkers

For Clinical Utility, Exosomes Require New Isolation and Analysis Tools

Image courtesy of Cline lab at Scripps Research

Biomarkers

Exosomes May Hold Key to Brain Circuit Development

Biomarkers

Newly Discovered Bacterial Natural Product Pathway Offers Potential for Synthetic Biology

Biomarkers

AI Based Predictors of Aging and Longevity Are on the Rise

Biomarkers

New Prostate Cancer Biomarker from Urine Could Eliminate Half of Treatments

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Key Genetic Regulators of Parkinson’s Disease Identified

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Antibiotic Discovery… There’s an App for That

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