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Tailored Cancer Drugs from New Cell Receptor Insights

New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored...

Biology by Design: Applying Gigabases of DNA to Bioengineering

REGISTER NOW Broadcast Date: March 21, 2019 Time: 8:00 am PT, 11:00 am ET, 16:00 CET For more than 15 years, the costs of DNA sequencing and...

Sangamo Shares Plunge after Interim Results for MPS Candidates Fall Short of Clinical Benefit

Shares of Sangamo Therapeutics lost about one-third of their value yesterday after the company released interim results from a pair of Phase I/II trials...

Young Blood Stays Young in the Old

The Fountain of Youth isn’t a literal fountain. It’s an epigenetic pattern, a collection of methylation marks on DNA, and it keeps remarkably steady...

DNA Mechanics Gets Cold

A team of physicists at the University of Basel have gone beyond studying the basic structures of biology, as structure alone is inadequate to...

Tortoise-Inspired Insulin Delivery Takes Its Time

Biologic drugs such as insulin commonly can’t be formulated as pills or capsules that are swallowed because the proteins or other biomacromolecules are degraded...

Cancer’s Metabolic Plasticity Pathways Decoded

A team from Rice University’s Center for Theoretical Biological Physics and the Baylor College of Medicine has created a basic framework of how cancer cells adapt when their attempts to metastasize are blocked by drugs or the body's immune system. Understanding the cells' strategies could someday help scientists design therapies that keep them in check.

Pancreatic Cancer Drug Production by Bacteria Uncovered

Streptozotocin (also known by the trade name Zanosar) is a known antibiotic compound and a drug used to treat metastatic pancreatic islet cell carcinoma....

Recurrent Tonsillitis Insights Might Lead to Strep Vaccine

Some kids suffer repeated bouts with step throat and tonsillitis, whereas other kids seem relatively immune. What accounts for the differences in susceptibility? Unfortunately,...

Prostate Cancer Prediction Looks to Machine Learning for Accuracy Boost

Diagnosing prostate cancer (PCa) has continually faced hurdles that have been difficult to overcome. The current diagnostic standard, the prostate-specific antigen or PSA test,...

Teenage Drinking Linked with Epigenetic Changes to Emotional Center of Brain

A study, headed by researchers at the University of Illinois at Chicago (UIC) Center for Alcohol Research in Epigenetics, of human brain tissue has found that binge drinking during adolescence causes epigenetic changes that could be linked with the development of psychological problems and alcohol use disorder (AUD) in adulthood.

Immunotherapy Shows Better Results by Boosting Antigen Presentation

Researchers at the University of Chicago working with scientists at Tsinghua University and the Chinese Academy of Sciences say they can boost the tumor control rate...

Filtration Focuses on Capacity and Concentration Pain Points

A therapeutic protein or monoclonal antibody (mAb) can be turned into an effective therapy and a revenue-generating product only if it can be efficiently...

Bispecific, Multispecific Antibodies Grapple with Cancer

Cancer immunotherapy has been advancing on several fronts, most strikingly in the direction of checkpoint inhibition and chimeric antigen receptor (CAR) T-cell therapy. Another...

Tissue Engineering Market in the U.S.

Since the term tissue engineering was coined in 1993, the fields of tissue engineering, regenerative medicine, and cell therapy have greatly matured from benchtop...

Tumor Microenvironments Are Target-Rich Environments

Pharmaceutical companies are investigating new lines of attack against cancer, which is, according to the World Health Organization, the world’s second leading cause of...

Incomplete Genomics: Adding New Sequences to the Reference Genome

Sequencing experts fill in gaps, confront genomic diversity, and ponder the complexities posed by multiple reference genomes

Epitope Mapping Sees around Corners

Antigenic forms of high interest often keep a low profile, frustrating investigators who would like to identify and characterize epitopes, the parts of antigens...

Back to the Future: Pre-CRISPR Systems Are Driving Therapies to the Clinic

In 2011, Cellectis chairman and CEO André Choulika, PhD, told his employees that the Paris-based company was changing course. It was dropping the early...

The Race Is On: What mRNA Product Will Reach the Market First?

The first “International mRNA Health Conference” was held in Tübingen, Germany, in 2013, initiated by mRNA (messenger RNA) platform companies CureVac, Moderna, and BioNTech....

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